Statistical Geneticist - Milano, Italia - Human Technopole

Human Technopole

Azienda verificata

Milano, Italia

2 settimane fa

Inviato da:

Piero Bianchi

Reclutatore di talenti per beBee

Descrizione

APPLICATION CLOSING DATE:
January 8th 2023

The Human Technopole Foundation (HT) is an interdisciplinary research institute created and supported by the Italian government, whose aim is to develop innovative strategies to promote human health and aging through a multidisciplinary and integrated approach, combining genomics, computational and structural biology and neuroscience, as well as data and decisions sciences.

The Health Data Science Centre at HT, in partnership with Politecnico di Milano, is developing several lines of research, with the aim to help deliver a step-change in health data science in Italy.

The Centre's mission is to systematically generate, mobilise, and harvest "big data" allowing agnostic and dynamic collection of information, to deliver a new class of research that will enable a better understanding of the clinical, molecular, behavioural and environmental determinants of non-communicable diseases, for both patient and public benefit.

Withing the Health Data Science Centre, the
Integrative Data Analysis Unit is** a state-of-the-art team dedicated to support analysis of large volumes of _multi-omic_ data from human populations and to perform integrative bioinformatics analysis and interpretation in relation to clinical data.

The Unit integrates a variety of processed molecular and clinical data types, with a particular focus on using genetics as an instrument to understand the molecular pathways from DNA to gene expression to protein.

Ultimately we aim to identify therapeutic targets of drugs that have high efficacy and low toxicity.

(S)He will have the following main responsibilities:

Running genetic association testing (eQTL and pQTL mapping, GWAS, PheWAS, etc.);
Postassociation analysis using summary statistics (metaanalysis, fine mapping, LD score regression, etc.) and particularly methods for causal inference and gene prioritisation (e.g. colocalisation, Mendelian randomisation);
Integrate genetic studies from diverse populations, including correcting for population structure, ethnicity or differences between genotyping platforms;
Explore the largely uncharted territory of the molecular characterization of eQTLs and pQTLs in relation to phenotype;
Identify molecular features important for drug targets success in clinical studies;
Working with colleagues in the Health Data Science Centre at HT and international collaborators from largescale consortia to help interpret and metaanalyse findings, and to develop and implement methodologically appropriate analysis strategies for planned investigations;

Essential

Strong fundamentals in applied multivariate statistics and experience working with statistical models for complex datasets, effectively measuring goodness of fit and estimating confidence;
Experience of statistical or other programming languages (preferably R) to manipulate largescale datasets (excellent data management and analysis skills);

Fluency in English

HT is an international research institute.

Advantageous

Experience in manipulating largescale datasets with genetic/molecular information;
Experience mining modern, largescale genetic databases (e.g. UK Biobank, UK10K, EBI GWAS Catalog, 1KG, ExAC/gnomAD, etc.);
Experience in a HPC environment.

Organizational and social skills

Ability to work accurately, with attention to detail;
Selfmotivated, able to work independently and organize own workload;
Highlevel report writing and presentation skills;
Good communication skills;
Good team player.

Application Instructions:

CV
A motivation letter in English
Names and contacts of 2 referees

Additional information

HT offers a highly collaborative, international culture to foster top quality, interdisciplinary research by promoting a vibrant environment consisting of independent research groups with access to outstanding graduate students, postdoctoral fellows and core facilities.

HT is an inclusive employer that fosters diversity and engages systematically to ensure that equal employment opportunities are provided without regard to age, race, creed, religion, sex, disability, medical condition, sexual orientation, gender identity or expression, national or ethnic origin or any other legally recognized status entitled to protection under applicable laws.

Number of positions offered: 1

Contract offered:
CCNL Chimico Farmaceutico, fixed-term, Employee level

The role is based in Milan.